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Products Details
Product Description
– TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].
Web ID
– HY-131404
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H16N4O2S
References
– [1]Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283(19):12819-12830.
CAS Number
– 6466-43-9
Molecular Weight
– 316.38
SMILES
– O=C(N1C)N(C)C2=C(N=C(CSCC3=CC=CC=C3)N2)C1=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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