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Products Details
Product Description
– TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF)[1].
Web ID
– HY-147936
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C50H70N10O16
References
– [1]Takeuchi T, et al. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2022 Jun 23;65(12):8493-8510.
CAS Number
– 2787582-17-4
Molecular Weight
– 1067.15
SMILES
– CC(C[C@@H](C(N([C@H](C(N1CCC[C@H]1CC(N)=O)=O)CCC(O)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCNC(C2=CC=C(OC3=CC=C(C(N)=O)C=C3)C=C2)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CCN)=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-2
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
