Download Files:
Products Details
Product Description
– Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties. Torilin inhibits LPS-induced NO release, as well as inhibiting iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF. Torilin suppresses NF-kB and AP-1 translocation, inhibits TAK1 kinase activation. Subsequently results suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation[1].
Web ID
– HY-N1140
Shipping
– Room temperature
Molecular Formula
– C22H32O5
References
– [1]Endale M, et al. Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF-κB Activation. Mediators Inflamm. 2017;2017:7250968.
CAS Number
– 13018-10-5
Molecular Weight
– 376.49
SMILES
– C/C=C(C)C(O[C@H]1[C@@H](C(C)(OC(C)=O)C)CC2=C(C)C(C[C@]2([H])[C@@H](C)C1)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– AP-1;MAP3K;NF-κB;p38 MAPK
Pathway
– Immunology/Inflammation;MAPK/ERK Pathway;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
