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Product Description
– Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability[1].
Web ID
– HY-152479
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H27Cl3N4O3
References
– [1]Skok Ž, et al. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold. Eur J Med Chem. 2023 Jan 18;249:115116.
Molecular Weight
– 537.87
SMILES
– O=C(NC1=C(OCC2=CC(C(NC3CCCNC3)=O)=CC=C2)C=CC=C1)C4=C(Cl)C(Cl)=C(C)N4.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Isoform
– Topo II
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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