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Products Details
Product Description
– Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629)[1].
Web ID
– HY-152187
Shipping
– Room temperature
Molecular Formula
– C25H30N2O5
References
– [1]Jeon KH, et al. Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Eur J Med Chem. 2023 Jan 15;246:114999.
Molecular Weight
– 438.52
SMILES
– O=C1C=C(OC2=CC(OCC(CNCCN3CCCCC3)O)=CC(O)=C12)C4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
