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Products Details
Product Description
– Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC50 of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis[1].
Web ID
– HY-146163
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H28BrN5O5S
References
– [1]Nemr MTM, et, al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2020 Dec;105:104446.
CAS Number
– 2697171-03-0
Molecular Weight
– 674.56
SMILES
– O=C(C1=C(C2=CC=CC=C2)N=C3SC4=C(N3C1C5=CC(OC)=C(C(OC)=C5)OC)N=C(N)N=C4C6=CC=C(Br)C=C6)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
