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Products Details
Product Description
– Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC50 is 0.17 μM for topo IIα and the value of IC50 is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential[1].
Web ID
– HY-143279
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H20N4O4
References
– [1]Zhi-Ying Li, et al. Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors. Bioorg Chem. 2022 Feb;119:105543.
CAS Number
– 99140-25-7
Molecular Weight
– 356.38
SMILES
– O=C1C2=C(C([N+]([O-])=O)=CC=C2NCCCN(C)C)NC3=C1C=C(O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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