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Product Description
– Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
Web ID
– HY-147861
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H21BrCl2N2O2S
References
– [1]Nemr MTM, et al. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorg Chem. 2020 Oct;103:104134.
CAS Number
– 2476559-00-7
Molecular Weight
– 588.34
SMILES
– O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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