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Product Description
– Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells[1].
Web ID
– HY-147839
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H20N6O7S
References
– [1]El-Helby AA, et al. Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors. Bioorg Chem. 2020 Oct;103:104233.
CAS Number
– 2488208-96-2
Molecular Weight
– 572.55
SMILES
– O=C(O)C1=CC=C(NC(CSC2=NN=C3N2N(CC(NC4=CC=C(C(O)=O)C=C4)=O)C(C5=C3C=CC=C5)=O)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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