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Product Description
– Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].
Web ID
– HY-151453
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H21NO2
References
– [1]Xu G, et al. Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents. Eur J Med Chem. 2022 Aug 26;243:114706.
CAS Number
– 2860554-26-1
Molecular Weight
– 367.44
SMILES
– O=C(NC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1)CCC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
