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Product Description
– Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1].
Web ID
– HY-143301
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H19FN4O
References
– [1]Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021).
CAS Number
– 2485135-31-5
Molecular Weight
– 386.42
SMILES
– O=C1C2=C(N=C3C4=CC5=CC=CC=C5C=C4CN13)C=C(C(F)=C2)N6CCNCC6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
