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Product Description
– Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].
Web ID
– HY-143266
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H14FNO3
References
– [1]Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May;122:105747.
CAS Number
– 2588211-50-9
Molecular Weight
– 311.31
SMILES
– COC1=C(C=C2N=C3COC4=C(C3=CC2=C1)C=C(F)C=C4)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Isoform
– Topo I
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
