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Products Details
Product Description
– Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect[1].
Web ID
– HY-143265
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H15NO3
References
– [1]Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May. 122:105747.
CAS Number
– 2588211-44-1
Molecular Weight
– 293.32
SMILES
– COC1=C(C=C2N=C3COC4=C(C3=CC2=C1)C=CC=C4)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;Topoisomerase
Isoform
– Topo I
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
