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Products Details
Product Description
– Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research[1].
Web ID
– HY-149002
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H21N5O6
References
– [1]Yang X, et al. Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity. J Med Chem. 2022 Jun 9;65(11):8040-8061.
Molecular Weight
– 511.49
SMILES
– O=C1C2=C(C(C3=C1C4=C(C=CC=C4)N3CC5=CN([C@H]6O[C@@H]([C@H](C6)O)CO)N=N5)=O)C7=C([N+]([O-])=C2)C=CC=C7
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Topoisomerase
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
