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Products Details
Product Description
– Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis[1].
Web ID
– HY-145859
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H14BrN3O2
References
– [1]Manasa Kadagathur, et al. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors. Bioorg Chem. 2022 May;122:105706.
CAS Number
– 2763655-68-9
Molecular Weight
– 408.25
SMILES
– O=C1NCC/C(C2=C1NC3=C2C=CC=C3)=C4C(NC5=C/4C=CC(Br)=C5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Reactive Oxygen Species;Topoisomerase
Isoform
– Topo I
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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