Download Files:
Products Details
Product Description
– Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway[1].
Web ID
– HY-150755
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H25ClN4O
References
– [1]Hu X, et al. Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy. Eur J Med Chem. 2022 Jun 23;240:114560.
CAS Number
– 2841455-91-0
Molecular Weight
– 420.93
SMILES
– ClC1=C(C(NC2=CC=CC=C2C(NC3=CC=C(C=C3)N4CCNCC4)=O)=CC=C1)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;COX;Reactive Oxygen Species;Topoisomerase
Isoform
– COX-2;Topo I
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
