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Products Details
Product Description
– Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].
Web ID
– HY-145852
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H32N8O4
References
– [1]Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702.
CAS Number
– 2775446-64-3
Molecular Weight
– 568.63
SMILES
– CN1C2=C(C(N3CCC4=C(C13)NC5=CC=C(C=C54)O)=O)C=C(C=C2)NCC6CCN(CC6)C7=NC=C(C=N7)C(NO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;Topoisomerase
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6;HDAC8;Topo I;Topo II
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
