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Tominersen
$760 – $2,700
Products Details
Product Description
– Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD)[1][2].
Web ID
– HY-132579
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C230H319N74O122P19S13
References
– [1]Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington’s Disease. N Engl J Med. 2019 Jun 13;380(24):2307-2316.|[2]Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington’s disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74(6):1031-44.
CAS Number
– 1709886-74-7
Molecular Weight
– 7078.00
Compound Purity
– 97.34
SMILES
– [Tominersen]
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Huntingtin
Pathway
– Neuronal Signaling
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
