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Products Details
Product Description
– Toddacoumalone is a natural inhibitor of phosphodiesterase 4 (PDE4) with moderate potency and imperfect agent-like properties. Toddacoumalone has the potential for the research of inflammatory diseases such as psoriasis[1].
Web ID
– HY-N10317
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H31NO6
References
– [1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65(5):4238-4254.
CAS Number
– 139750-79-1
Molecular Weight
– 513.58
SMILES
– C/C(C)=C[C@H]1C2=C(O[C@](C)(C1)/C=C/C3=C4C(C=CC(O4)=O)=C(C=C3OC)OC)C5=CC=CC=C5N(C2=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
