Products Details

Product Description

– TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].

Web ID

– HY-153259

Shipping

– Room temperature

Molecular Formula

– C26H24F3N3O4

References

– [1]Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010.

CAS Number

– 1498300-35-8

Molecular Weight

– 499.48

SMILES

– O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PARP

Pathway

– Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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