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Products Details
Product Description
– TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases[1].
Web ID
– HY-149331
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H26N2O5
References
– [1]Yang Y, et al. Structure-Based Drug Design and Synthesis of Pyrrolidine-2,5-diones as Novel TNF-α Inhibitors. J Chem Inf Model. 2023 Jun 26;63(12):3911-3924.
Molecular Weight
– 422.47
SMILES
– O=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Caspase;NF-κB;TNF Receptor
Pathway
– Apoptosis;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
