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Products Details
Product Description
– TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-154361
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H19N5O6
References
– [1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.
CAS Number
– 2389988-70-7
Molecular Weight
– 389.36
SMILES
– O=C1N(CC#C)C2=C(N=C(N)N=C2)N1[C@@H]3O[C@H](COC(C)=O)C[C@H]3OC(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Nucleoside Antimetabolite/Analog
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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