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Products Details
Product Description
– TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].
Web ID
– HY-153544
Shipping
– Room temperature
Molecular Formula
– C20H26N6O
References
– [1]Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.
CAS Number
– 2649170-17-0
Molecular Weight
– 366.46
SMILES
– NC1=NC(NCCOC)=C2C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Toll-like Receptor (TLR)
Isoform
– TLR7;TLR8
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
