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Products Details
Product Description
– TL02-59 dihydrochloride is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. TL02-59 dihydrochloride inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 dihydrochloride potently suppresses acute myelogenous leukemia (AML) cell growth[1].
Web ID
– HY-112852A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H36Cl2F3N5O4
References
– [1]Weir MC, et al. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559.
CAS Number
– 2415263-06-6
Molecular Weight
– 682.56
SMILES
– O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C=C(OC)C(OC)=CC5=NC=N4)=C3.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Src
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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