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Tin protoporphyrin IX dichloride
SKU
HY-101194-10 mg
Category Reference compound
Tags Cancer, Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB, Reactive Oxygen Species
$130 – $210
Products Details
Product Description
– Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].
Web ID
– HY-101194
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C34H32Cl2N4O4Sn
References
– [1]Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.
CAS Number
– 14325-05-4
Molecular Weight
– 750.26
Compound Purity
– 95.0
SMILES
– [Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5)[Cl-]
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 0.1 M NaOH : 14.29 mg/mL (ultrasonic;adjust pH to 12 with NaOH)|1M NaOH : 5 mg/mL (ultrasonic)|DMF : 1 mg/mL (ultrasonic;warming)|DMSO : 0.5 mg/mL (ultrasonic;warming)
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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