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Products Details
Product Description
– Tilsotolimod is a synthetic Toll-like receptor 9 (TLR9) agonist that has demonstrated antitumor activity in preclinical models.
Web ID
– HY-150212
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C223H284N74O115P22S22
References
– [1]Karime C, Wang J, Woodhead G, et al. Tilsotolimod: an investigational synthetic toll-like receptor 9 (TLR9) agonist for the treatment of refractory solid tumors and melanoma. Expert Opin Investig Drugs. 2022;31(1):1-13.|[2]Haymaker C, Johnson DH, Murthy R, et al. Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma. Cancer Discov. 2021;11(8):1996-2013.|[3]Babiker H, Borazanci E, Subbiah V, et al. Tilsotolimod Exploits the TLR9 Pathway to Promote Antigen Presentation and Type 1 IFN Signaling in Solid Tumors: A Multicenter International Phase I/II Trial (ILLUMINATE-101). Clin Cancer Res. 2022;28(23):5079-5087.
CAS Number
– 1948266-37-2
Molecular Weight
– 7228.00
SMILES
– [Tilsotolimod]
Clinical Information
– Phase 3
Research Area
– cancer
Solubility
– 10 mM in H2O
Target
– Toll-like Receptor (TLR)
Pathway
– Immunology/Inflammation
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
