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Products Details
Product Description
– Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH)[1]. Tiazofurin also has anti-orthopoxvirus and anti-variola activities[2].
Web ID
– HY-114570
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H12N2O5S
References
– [1]Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170. |[2]Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.
CAS Number
– 60084-10-8
Molecular Weight
– 260.27
SMILES
– O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Nucleoside Antimetabolite/Analog;Orthopoxvirus
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
