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Product Description
– Thyroxine hydrochloride-13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
Web ID
– HY-18341S1
Shipping
– Room temperature
Molecular Formula
– C9 13C6H12ClI4NO4
References
– [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1421769-38-1
Molecular Weight
– 819.29
SMILES
– IC(C=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13C]2I)C[C@H](N)C(O)=O)I)=C(C(I)=C1)O.Cl
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Isotope-Labeled Compounds;Thyroid Hormone Receptor
Pathway
– Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
