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Products Details
Product Description
– THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition[1].
Web ID
– HY-150169
Shipping
– Room temperature
Molecular Formula
– C26H28ClF2N7
References
– [1]Maher JM, et, al. Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition. Toxicol Appl Pharmacol. 2022 Mar 1;438:115905.
CAS Number
– 2442519-59-5
Molecular Weight
– 512.00
SMILES
– FC1=CC(F)=C(C2=NNC=C2C3=NC4=C(C=C3)N=CC(NCCN5CCN(C(C)C)CC5)=C4)C=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TGF-β Receptor
Isoform
– ALK5
Pathway
– TGF-beta/Smad
Product type
– Reference compound
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