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Products Details
Product Description
– ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities[1].
Web ID
– HY-146263
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H30Cl2N6O5
References
– [1]Cai Z, et al. Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. J Med Chem. 2022;65(7):5800-5820.
Molecular Weight
– 637.51
SMILES
– O=C(NC[C@@H](C1=CC(C2=CC(CN3)=C(C=C2)C3=O)=CC=C1)NC([C@@H](N)[C@@H](C)O)=O)CCN4C=NC5=C(C4=O)C=C(Cl)C(Cl)=C5
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
