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Product Description
– Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2].
Web ID
– HY-113350
Shipping
– Room temperature
Molecular Formula
– C20H32O5
References
– [1]Matthew A Sparks, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013 Jan;61(1):166-73.|[2]Federica Moalli, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.
CAS Number
– 57576-52-0
Molecular Weight
– 352.47
SMILES
– O=C(O)CCC/C=CC[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@]2([H])O[C@@]1([H])C2
Clinical Information
– Phase 2
Research Area
– Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Prostaglandin Receptor
Isoform
– Human Endogenous Metabolite;TXA2/TP
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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