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Theaflavin 3,3′-digallate
$105 – $377
Products Details
Product Description
– Theaflavin 3,3′-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3′-digallat directly binds to ZIKVpro (Kd=8.86 µM) and inhibits ZIKV replication. Theaflavin 3,3′-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1[1]. Theaflavin 3,3′-digallate, the typical pigment in black tea, is a potent antitumor agent[2].
Web ID
– HY-N1992
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C43H32O20
References
– [1]Xiangling Cui, et al. Identification of Theaflavin-3,3′-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.|[2]Ding Y, et al. Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line. Food Nutr Res. 2017 Nov 15;61(1):1400340.
CAS Number
– 30462-35-2
Molecular Weight
– 868.70
Compound Purity
– 99.73
SMILES
– O=C(C1=CC(O)=C(C(O)=C1)O)O[C@H]2[C@H](OC3=CC(O)=CC(O)=C3C2)C4=C5C(C(C(O)=CC([C@@H]6[C@@H](CC7=C(O)C=C(O)C=C7O6)OC(C8=CC(O)=C(C(O)=C8)O)=O)=C5)=O)=C(C(O)=C4)O
Clinical Information
– Phase 1
Research Area
– Cancer; Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Flavivirus;HIV;HSV;Virus Protease
Isoform
– HIV-1;HSV
Pathway
– Anti-infection
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
