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Products Details
Product Description
– Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].
Web ID
– HY-W457950
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Molecular Formula
– C16H12N2O5
References
– [1]Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.
CAS Number
– 2226303-74-6
Molecular Weight
– 312.28
Compound Purity
– 95.87
SMILES
– O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(OCC#C)=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
