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Thalidomide-4-O-C6-NH2 (TFA)
$350 – $950
Products Details
Product Description
– Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12F36V and BET[1].
Web ID
– HY-135250A
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H24F3N3O7
References
– [1]Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274.
CAS Number
– 1957235-99-2
Molecular Weight
– 487.43
Compound Purity
– 97.0
SMILES
– O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
