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Thalidomide-4-O-C2-NH2 (hydrochloride)
SKU
HY-136162-10 mg
Category Reference compound
Tags Cancer, E3 Ligase Ligand-Linker Conjugates, PROTAC
$64 – $320
Products Details
Product Description
– Thalidomide 4′-ether-alkylC2-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Web ID
– HY-136162
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H16ClN3O5
References
– [1]Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556.
CAS Number
– 2341840-99-9
Molecular Weight
– 353.76
Compound Purity
– 99.37
SMILES
– O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCN)=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
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