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Thailanstatin D
SKU
HY-139104-10mg
Category Natural Products
Tags Apoptosis;Cell Cycle/DNA Damage, Apoptosis;DNA/RNA Synthesis, Cancer
Products Details
Product Description
– Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3′ splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis[1].
Web ID
– HY-139104
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H41NO8
References
– [1]Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130.
CAS Number
– 1609105-89-6
Molecular Weight
– 519.63
SMILES
– C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(C[C@H](O2)CC(O)=O)CO3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;DNA/RNA Synthesis
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.