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TH1217
$160 – $1,330
Products Details
Product Description
– TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2].
Web ID
– HY-135909
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C20H17BCl2N4O6
References
– [1]Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148.|[2]Gordon DE, et, al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22; 2020.03.22.002386.
CAS Number
– 1862212-48-3
Molecular Weight
– 491.09
Compound Purity
– 99.73
SMILES
– CC1=NC2=C(C(Cl)=C(Cl)C=C2N1CC3=CC=C(C=C3)[B-]45OC(C[N+]4(C)CC(O5)=O)=O)[N+]([O-])=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– SARS-CoV
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
