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Products Details
Product Description
– TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].
Web ID
– HY-155306
Shipping
– Room temperature
Molecular Formula
– C28H48O5
References
– [1]Emiliano Rosatelli, et al. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. Eur J Med Chem. 2023 Oct 1:261:115851.
CAS Number
– 2148317-51-3
Molecular Weight
– 464.68
SMILES
– C[C@@H]([C@]1(CC[C@]2([C@@]3([C@](O)(C[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@]12C)O)[H])C)O)[H])CCCC)[H])[H])[H])CCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– G protein-coupled Bile Acid Receptor 1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
