Download Files:
Products Details
Product Description
– TGR5 agonist 1 (compound 18) is a potent TGR5 agonist with an EC50 value of 0.31 µM[1].
Web ID
– HY-149807
Shipping
– Room temperature
Molecular Formula
– C28H48NNaO6S
References
– [1]Luxenburger A, et al. The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists. Eur J Med Chem. 2023 Mar 15;250:115143.
Molecular Weight
– 549.74
SMILES
– [H][C@]12C[C@@H](C)[C@]3([H])[C@](CC[C@@]3([H])[C@]1([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@@]42C)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– G protein-coupled Bile Acid Receptor 1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
