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Products Details
Product Description
– TGFβRI-IN-5 (Compound 4b) is a potent inhibitor of TGFβRI with an IC50 of 0.08 μM. TGFβRI-IN-5 displays amazing anticancer activity 5–7 times that of reference agent against all the tested cell lines. TGFβRI-IN-5 enhances apoptosis and arrested G2/M phase of cell cycle[1].
Web ID
– HY-147786
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H12N2O6
References
– [1]Ismail MMF, et al. Design and synthesis of novel tranilast analogs: Docking, antiproliferative evaluation and in-silico screening of TGFβR1 inhibitors. Bioorg Chem. 2020;105:104368.
CAS Number
– 2541690-15-5
Molecular Weight
– 328.28
SMILES
– CC(N(C1=CC=CC=C1C(O)=O)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TGF-β Receptor
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
