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Products Details
Product Description
– TGFβR-IN-1 is a long-acting tumor-activated proagent of a TGFβR inhibitor.
Web ID
– HY-139858
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C84H121ClFN17O23
References
– [1]Zhang Y, et al. Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor. J Med Chem. 2021 Nov 11;64(21):15787-15798.
CAS Number
– 2857845-36-2
Molecular Weight
– 1791.41
SMILES
– O=C(OCC1=CC=C(NC([C@H](CCCCN)NC(CNC([C@@H](NC([C@H](CC(C)C)NC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)C(O)=O)=O)=O)=O)=O)CO)=O)=O)=O)C=C1)NCOCCN2C=NC(C3=CC(Cl)=C(F)C=C3)=C2C(C=C4)=NN5C4=NC=C5C#N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– TGF-β Receptor
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
