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Products Details
Product Description
– TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].
Web ID
– HY-146434
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H22N2O4
References
– [1]Dexin Deng, et al. Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis. Eur J Med Chem. 2020 Jan 1;185:111790.
CAS Number
– 2387678-02-4
Molecular Weight
– 378.42
SMILES
– O=C(NC1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O)CN4CCCCC4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– TGF-beta/Smad
Pathway
– Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
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