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Tezacitabine
$970 – $4,900
Products Details
Product Description
– Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment[1][2].
Web ID
– HY-106014
Storage Temperature
– -80°C
Shipping
– Dry Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C10H12FN3O4
References
– [1]Janusz S Skierski, et al. Tezacitabine Blocks Tumor Cells in G1 and S Phases of the Cell Cycle and Induces Apoptotic Cell Death. Acta Pol Pharm. May-Jun 2005;62(3):195-205.|[2]Pietro Taverna, et al. Tezacitabine Enhances the DNA-directed Effects of Fluoropyrimidines in Human Colon Cancer Cells and Tumor Xenografts. Biochem Pharmacol. 2007 Jan 1;73(1):44-55.
CAS Number
– 130306-02-4
Molecular Weight
– 257.22
Compound Purity
– 99.35
SMILES
– F/C=C1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]/1O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 200 mg/mL (ultrasonic)|H2O : 200 mg/mL (ultrasonic)
Target
– Apoptosis;DNA/RNA Synthesis;Nucleoside Antimetabolite/Analog
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
