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Products Details
Product Description
– Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the research of cancer, including colorectal and gastric cancer.
Web ID
– HY-16491
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C46H60FN3O13
References
– [1]Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci. 2003;94(5):459-466. |[2]Saif MW, Sarantopoulos J, Patnaik A, Tolcher AW, Takimoto C, Beeram M. Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2011;68(6):1565-1573.
CAS Number
– 333754-36-2
Molecular Weight
– 881.98
SMILES
– CC(O[C@]12[C@]3([H])[C@]([C@@]4([H])[C@@](O[C@H](O4)CN(C)C)([H])C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=C(C=CC=N6)F)NC(OC(C)(C)C)=O)=O)C[C@@](O)([C@H]3OC(C7=CC=CC=C7)=O)C5(C)C)(CC[C@@]1([H])OC2)C)=O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
