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Products Details
Product Description
– Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence[1][2].
Web ID
– HY-16489
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H27N
References
– [1]H D Langtry, et al. Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence. Drugs. 1990 Nov;40(5):748-61. |[2]Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol. 2006 Nov;48(5):199-206.
CAS Number
– 15793-40-5
Molecular Weight
– 281.44
SMILES
– CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;mAChR;Potassium Channel
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
