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Product Description
– Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
Web ID
– HY-17395AS
Shipping
– Room temperature
Molecular Formula
– C21H19D7ClN
References
– [1]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.|[2]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7.|[3]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1185240-27-0
Molecular Weight
– 334.93
SMILES
– CC(C)(C)C#C/C=C/CN(C)CC1=C([2H])C([2H])=C([2H])C2=C1C([2H])=C([2H])C([2H])=C2[2H].Cl[H]
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Fungal;Isotope-Labeled Compounds
Pathway
– Anti-infection;Others
Product type
– Isotope-Labeled Compounds
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