Download Files:
Tenofovir Disoproxil (fumarate)
$35 – $308
Products Details
Product Description
– Tenofovir Disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B.
Web ID
– HY-13782
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C23H34N5O14P
Citations
– Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|J Gastroenterol. 2021 Feb;56(2):168-180.|J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.|J Neuroimmune Pharmacol. 2019 Jul 23;10.1007/s11481-019-09862-1.|Sci Rep. 2019 Nov 20;9(1):17158. |Department od Analytical Chemistry, Charles University. 2019 Jun.
References
– [1]Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.|[2]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018|[3]Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098|[4]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3)|[5]Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.
CAS Number
– 202138-50-9
Molecular Weight
– 635.51
Compound Purity
– 99.67
SMILES
– O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O.O=C(O)/C=C/C(O)=O
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 16.67 mg/mL (ultrasonic;warming)
Target
– HBV;HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
