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Products Details
Product Description
– Ten01 has 5.0 nM activity against JAK1 kinase.
Web ID
– HY-139649
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H20F6N4O
References
– [1]Yu Y, et al. A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors. ACS Omega. 2021 Aug 24;6(35):22945-22954.
Molecular Weight
– 422.37
SMILES
– FC(F)(F)C1=CN=C(NC=C2)C2=C1C[C@H]3CN(C(NCC(F)(F)F)=O)C[C@@H]3CC
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– JAK
Isoform
– JAK1
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
