Products Details

Product Description

– Tegaserod-13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].

Web ID

– HY-14153AS

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C19 13CH24D3N5O5

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[2]A E Vickers, et al. In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos. 2001 Oct;29(10):1269-76.|[3]D T Beattie, et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60.|[4]H-C Pan, et al. Tegaserod, a small compound mimetic of polysialic acid, promotes functional recovery after spinal cord injury in mice. Neuroscience. 2014 Sep 26;277:356-66.|[5]M D Crowell, et al. The effects of tegaserod, a 5-HT receptor agonist, on gastric emptying in a murine model of diabetes mellitus. Neurogastroenterol Motil. 2005 Oct;17(5):738-43.|[6]T C Seerden, et al. Experimental pancreatitis disturbs gastrointestinal and colonic motility in mice: effect of the prokinetic agent tegaserod. Neurogastroenterol Motil. 2007 Oct;19(10):856-64.

Molecular Weight

– 421.47

SMILES

– N=C(N/N=C/C1=CNC2=C1C=C(O[13C]([2H])([2H])[2H])C=C2)NCCCCC.O=C(O)/C=CC(O)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– 5-HT Receptor;Isotope-Labeled Compounds

Pathway

– GPCR/G Protein;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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