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Products Details
Product Description
– TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis[1].
Web ID
– HY-139038
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H15ClN2O6
References
– [1]Tracy M Neher, et al. Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS Chem Biol. 2010 Oct 15;5(10):953-65.
CAS Number
– 292065-64-6
Molecular Weight
– 450.83
SMILES
– O=C(O)C1=CC(C2=CC=C(/C=C3C(C)=NN(C4=CC=CC(C(O)=O)=C4)C3=O)O2)=CC=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
